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One consequence is a decreased or modified production of some major precursors for the neuroactive steroid synthesis occurring in the skin, mucosa, and nervous system(e.g., androstenedione and testosterone sulfate, 5alpha-androstane-3α,17β-diol), as well as an increase in urinary 5-alpha-dihydrotestosterone due to lower serum T (see Chapter 10) (see Table 17). An alternative possibility is that anabolic steroid abuse causes a shift in the normal balance of anabolic (androgenic) and androgenic (estrogenic) hormones, resulting in diminished neuroendocrine sensitivity, illegal steroids for sale uk. Thus, as a result of the anabolic-androgenic imbalance produced by abuse, a greater proportion of androgens is converted to its inactive metabolite, 5-alpha-dihydroestradiol (5-hE 2 ) (see Figure 16), as seen in the increased level of this metabolite in urine of many steroids abusers. This increased conversion of anabolic steroids to 5-hE 2 suggests that anabolic-androgenic imbalance is also present in anabolic steroid abusers (see Chapter 10), neuroactive tablet. While evidence supporting the latter conclusion is more limited (see Chapter 10), studies show lower serum 5-hE 2 levels in both anabolic-androgenic steroid-abusing and non-abusing athletes as well as in the serum of healthy men participating in competitive sports (see Figure 17). In addition, serum 5-hE 2 also appears to be lower in anabolic steroid abusers when compared to healthy men who have not committed anabolic-androgenic steroid abuse (see Figure 18). A final consequence of anabolic steroids is that anabolic steroid abuse reduces the levels of growth hormone (GH) in the body, causing decreased testosterone production and, ultimately, decreased testicular volume, illegal steroids for sale uk. This is one of the primary causes of enlargement of the testicles in adolescents with GHD. In the majority of individuals who take anabolic steroids, serum levels of ACTH appear unchanged (and at most may be slightly decreased) while GH levels are reduced or eliminated (see Chapter 3), neuroactive tablet. Thus, although it is assumed that increased growth hormone production may promote the growth of skeletal muscle, this may not be the case with the anabolic-androgenic-steroid users. Anabolic steroids may also affect pituitary function, leading to the development of GHD, illegal steroids for sale online. Studies show that anabolic steroid abusers display a greater incidence of pituitary dysfunction and GHD (see Chapter 3).
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